Animal-Free Recombinant Human IL -22

Grouped product items
Size Price Qty
10µg
$215.00
100µg
$1,140.00
500µg
$3,420.00
1mg
$5,700.00
Catalog Number : AF-200-22

description

IL-22 is a member of the IL-10 family of regulatory cytokines which includes IL-10, IL-19, IL-20, IL-22, IL-24 and IL-26. Members of this family share partial homology in their amino acid sequences, but they are dissimilar in their biological functions. Produced by T lymphocytes, IL-22 inhibits IL-4 production by Th2 cells, and induces acute phase reactants in the liver and pancreas. IL-22 signals through a receptor system consisting of IL-10R-β/CRF2-4 and IL-22R, both of which are members of the class II cytokine-receptor family. Recombinant human IL-22 is a 33.6 kDa non-disulfide-linked homodimeric protein containing of two 146 amino acid polypeptide chains. Manufactured using all non-animal reagents.

Additional Information

Source:
E. Coli
Purity:
Above 98% as determined by SDS-PAGE Analysis.
Cross Reactivity:
NULL
Biological Activity
Assay #1: Determined by its ability to activate STAT following receptor ligand interaction.
Assay #2: Measured by its ability to induce IL-10 secretion in COLO 205 (human colon carcinoma cells). The expected ED
AA Sequence
MAPISSHCR LDKSNFQQP YITNRTFML AKEASLADN NTDVRLIGE KLFHGVSMS ERCYLMKQV LNFTLEEVL FPQSDRFQP YMQEVVPFL ARLSNRLST CHIEGDDLH IQRNVQKLK DTVKKLGES GEIKAIGEL DLLFMSLRN ACI
Research Interest: Adaptive Immunity, Immunology
Cell Type: T Cells
Application: FA
Protein Cross Reactivity: NULL
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