Animal-Free Recombinant Human IL-15
IL-15 is an immunomodulating cytokine that stimulates the proliferation of T lymphocytes and shares many biological properties with IL-2. IL-15 exerts its biological activites primarily on T cells. It is also essential in the development, survival and activation of NK cells. Increased expression of IL-15 has been implicated with rheumatoid arthritis, inflammatory bowel disease and diseases affiliated with retroviruses HIV and HTLV-I. Human IL-15 is biologically active on mouse cells as measured by the dose-dependent stimulation of the proliferation of mouse CTLL cells. Recombinant human IL-15 is a 12.9 kDa protein consisting of 114 amino acid residues. Manufactured using all non-animal reagents.
Above 98% as determined by SDS-PAGE Analysis.
The ED50 as determined by the dose-dependent stimulation of the proliferation of CTLL-2 cells was found to be ≤ 0.5 ng/ml, corresponding to a specific activity of ≥ 2 x 106 units/mg.
MNWVNVISD LKKIEDLIQ SMHIDATLY TESDVHPSC KVTAMKCFL LELQVISLE SGDASIHDT VENLIILAN NSLSSNGNV TESGCKECE ELEEKNIKE FLQSFVHIV QMFINTS
|Research Interest:||Innate Immunity, Adaptive Immunity, Stem Cell Research, Apoptosis, Immunology, Cancer, Inflammation|
|Cell Type:||NK and NKT Cells, T Cells|
|Protein Cross Reactivity:||Monkey, Mouse|