Animal-Free Recombinant Human IL-10
IL-10 is an immunosuppressive cytokine produced by a variety of mammalian cell types including macrophages, monocytes, T cells, B cells and keratinocytes. IL-10 inhibits the expression of proinflammatory cytokines such as IL-1 and TNFα. Like IL-4, IL-10 enhances humoral immune responses and attenuates cell-mediated immune reactions. Human IL-10 active on murine cells, but murine IL-10 is inactive on human cells. Recombinant human IL-10 is an 18.6 kDa protein of 161 amino acid residues. Manufactured using all non-animal reagents.
Above 98% as determined by SDS-PAGE Analysis.
Bacteria, Monkey, Mouse, Virus
Determined by the dose-dependent co-stimulation (with human IL-4) of MC/9 cells. The ED50 was found to be ≤ 2.0 ng/ml, corresponding to a specific activity of ≥ 5 x 105 units/mg.
MSPGQGTQS ENSCTHFPG NLPNMLRDL RDAFSRVKT FFQMKDQLD NLLLKESLL EDFKGYLGC QALSEMIQF YLEEVMPQA ENQDPDIKA HVNSLGENL KTLRLRLRR CHRFLPCEN KSKAVEQVK NAFNKLQEK GIYKAMSEF DIFINYIEA YMTMKIRN
|Research Interest:||Innate Immunity, Stem Cell Research, Immunology, Cancer, Neurosciences, Inflammation|
|Cell Type:||B Cells, Macrophage / Monocyte, T Cells, T Regulatory Cells|
|Protein Cross Reactivity:||Bacteria, Monkey, Mouse, Virus|