Animal-Free Recombinant Human IL-10

Grouped product items
SizePrice Qty
10µg
$215.00
100µg
$1,140.00
500µg
$3,420.00
1mg
$5,700.00
Catalog Number : AF-200-10

description

IL-10 is an immunosuppressive cytokine produced by a variety of mammalian cell types including macrophages, monocytes, T cells, B cells and keratinocytes. IL-10 inhibits the expression of proinflammatory cytokines such as IL-1 and TNFα. Like IL-4, IL-10 enhances humoral immune responses and attenuates cell-mediated immune reactions. Human IL-10 active on murine cells, but murine IL-10 is inactive on human cells. Recombinant human IL-10 is an 18.6 kDa protein of 161 amino acid residues. Manufactured using all non-animal reagents.

Additional Information

Source:
E. Coli
Purity:
Above 98% as determined by SDS-PAGE Analysis.
Cross Reactivity:
Bacteria, Monkey, Mouse, Virus
Biological Activity
Determined by the dose-dependent co-stimulation (with human IL-4) of MC/9 cells. The ED50 was found to be ≤ 2.0 ng/ml, corresponding to a specific activity of ≥ 5 x 105 units/mg.
AA Sequence
MSPGQGTQS ENSCTHFPG NLPNMLRDL RDAFSRVKT FFQMKDQLD NLLLKESLL EDFKGYLGC QALSEMIQF YLEEVMPQA ENQDPDIKA HVNSLGENL KTLRLRLRR CHRFLPCEN KSKAVEQVK NAFNKLQEK GIYKAMSEF DIFINYIEA YMTMKIRN
Research Interest:Innate Immunity, Stem Cell Research, Immunology, Cancer, Neurosciences, Inflammation
Cell Type:B Cells, Macrophage / Monocyte, T Cells, T Regulatory Cells
Application:FA
Protein Cross Reactivity:Bacteria, Monkey, Mouse, Virus
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