Recombinant Human IFN-λ2
Catalog Number : 300-02K
IFN -λ-1,-2, and -3 (also known as IL-29, IL-28A and IL-28B respectively) are distantly related to the IL-10 family and Interferons. All three IFN-λs uses a distinct receptor system composed of an IFN-λR1 subunit (also called CRF2-12) and IL-10R2 subunit (also called CRF2-14). Signaling through this receptor system induces antiviral defense similar but distinct than the type I Interferons.(Kotenko, SV. et al. Nat Immunology 2003  p. 69-77). Recombinant human IFN-λ 2 is a 19.6 kDa protein containing 174 amino acid residues.
Above 98% as determined by SDS-PAGE Analysis.
Determined by its ability to activate STAT phosphorylation in an ISRE Luciferase Reporter Assay using human colon carcinoma COLO205 cells. The expected ED50 is 0.3-0.5 ng/ml.
PVARLHGAL PDARGCHIA QFKSLSPQE LQAFKRAKD ALEESLLLK DCRCHSRLF PRTWDLRQL QVRERPMAL EAELALTLK VLEATADTD PALVDVLDQ PLHTLHHIL SQFRACIQP QPTAGPRTR GRLHHWLYR LQEAPKKES PGCLEASVT FNLFRLLTR DLNCVASGD LCV
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