Recombinant Human IFN-λ1
Catalog Number : 300-02L
description
IFN λ-1,-2, and -3 (also known as IL-29, IL-28A and IL-28B respectively) are distantly related to the IL-10 family and Interferons. All three IFN-λs use a distinct receptor system composed of an IFN-λR1 subunit (also called CRF2-12) and IL-10R2 subunit (also called CRF2-14). Signaling through this receptor system induces antiviral defense similar but distinct than the type I Interferons. (Kotenko, SV. et al. Nat Immunology 2003 [1] p. 69-77). Recombinant human IFN-λ 1 is a 19.8 kDa protein containing 178 amino acid residues.
Additional Information
Source: | E. Coli |
Purity: | Above 98% as determined by SDS-PAGE Analysis. |
Cross Reactivity: | NULL |
Biological Activity | Determined by its ability to activate STAT phosphorylation in an ISRE Luciferase Reporter Assay using human colon carcinoma COLO205 cells. The expected ED50 is 0.2-0.5 ng/ml. |
AA Sequence | PTSKPTTTG KGCHIGRFK SLSPQELAS FKKARDALE ESLKLKNWS CSSPVFPGN WDLRLLQVR ERPVALEAE LALTLKVLE AAAGPALED VLDQPLHTL HHILSQLQA CIQPQPTAG PRPRGRLHH WLHRLQEAP KKESAGCLE ASVTFNLFR LLTRDLKYV ADGNLCLRT STHPEST |
| Application: | FA |
|---|---|
| Protein Cross Reactivity: | NULL |