Recombinant Human IFN-λ1

Grouped product items
SizePrice Qty
5µg
$80.00
20µg
$195.00
100µg
$600.00
500µg
$1,800.00
1mg
$3,000.00
Catalog Number : 300-02L

description

IFN λ-1,-2, and -3 (also known as IL-29, IL-28A and IL-28B respectively) are distantly related to the IL-10 family and Interferons. All three IFN-λs use a distinct receptor system composed of an IFN-λR1 subunit (also called CRF2-12) and IL-10R2 subunit (also called CRF2-14). Signaling through this receptor system induces antiviral defense similar but distinct than the type I Interferons. (Kotenko, SV. et al. Nat Immunology 2003 [1] p. 69-77). Recombinant human IFN-λ 1 is a 19.8 kDa protein containing 178 amino acid residues.

Additional Information

Source:
E. Coli
Purity:
Above 98% as determined by SDS-PAGE Analysis.
Cross Reactivity:
NULL
Biological Activity
Determined by its ability to activate STAT phosphorylation in an ISRE Luciferase Reporter Assay using human colon carcinoma COLO205 cells. The expected ED50 is 0.2-0.5 ng/ml.
AA Sequence
PTSKPTTTG KGCHIGRFK SLSPQELAS FKKARDALE ESLKLKNWS CSSPVFPGN WDLRLLQVR ERPVALEAE LALTLKVLE AAAGPALED VLDQPLHTL HHILSQLQA CIQPQPTAG PRPRGRLHH WLHRLQEAP KKESAGCLE ASVTFNLFR LLTRDLKYV ADGNLCLRT STHPEST
Application:FA
Protein Cross Reactivity:NULL
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