Animal-Free Recombinant Human IFN-γ

Grouped product items
SizePrice Qty
100µg
$215.00
250µg
$420.00
500µg
$720.00
1mg
$1,200.00
Catalog Number : AF-300-02

description

IFN-γ is an acid-labile interferon produced by CD4 and CD8 T lymphocytes as well as activated NK cells. IFN-γ receptors are present in most immune cells, which respond to IFN-γ signaling by increasing the surface expression of class I MHC proteins. This promotes the presentation of antigen to T-helper (CD4+) cells. IFN-γ signaling in antigen-presenting cells and antigen-recognizing B and T lymphocytes regulate the antigen-specific phases of the immune response. Additionally, IFN-γ stimulates a number of lymphoid cell functions including the anti-microbial and anti-tumor responses of macrophages, NK cells, and neutrophils. Human IFN-γ species-specific and is biologically active only in human and primate cells. Recombinant human IFN-γ is a 16.8 kDa protein containing 144 amino acid residues. Manufactured using all non-animal reagents.

Additional Information

Source:
E. Coli
Purity:
Above 98% as determined by SDS-PAGE Analysis.
Cross Reactivity:
Monkey
Biological Activity
Assay #1: Determined by its ability to induce apoptosis in HeLa cells. The expected ED50 for this effect is 5.0-10.0 ng/ml.
Assay #2: The ED50 was determined by a cytotoxicity assay using HT-29
AA Sequence
MQDPYVKEA ENLKKYFNA GHSDVADNG TLFLGILKN WKEESDRKI MQSQIVSFY FKLFKNFKD DQSIQKSVE TIKEDMNVK FFNSNKKKR DDFEKLTNY SVTDLNVQR KAIHELIQV MAELSPAAK TGKRKRSQM LFQGRRASQ
Research Interest:Innate Immunity, Stem Cell Research, Immunology, Cancer, Angiogenesis, Neurosciences, Metabolic Regulation and Diabetes
Cell Type:B Cells, Macrophage / Monocyte, NK and NKT Cells, T Regulatory Cells
Application:FA
Protein Cross Reactivity:Monkey
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