Recombinant Human IGF-BP6

Grouped product items
Size Price Qty
5µg
$80.00
20µg
$195.00
100µg
$850.00
500µg
$3,120.00
1mg
$5,200.00
Catalog Number : 350-07B

description

IGF-BPs controls the distribution, function and activity of IGFs in various cell tissues and body fluids. IGF-BP6 is produced by bone cells and is the major IGF-BP present in cerebrospinal fluid, and specifically inhibits IGF-II actions. IGF-BP6 has been shown to inhibit IGF-II-dependent cancers such as neuroblastoma, colon cancer and rhabdomyosarcoma. Recombinant human IGF-BP6 has a calculated mass of 22.6 kDa and consists of 213 amino acid residues including the IGF-BP domain and thyroglobulin type-I domain. IGF-BP6 migrates at an apparent molecular weight of approximately 23.0-30.0 kDa by SDS-PAGE analysis under non-reducing conditions.

*Manufactured using (BTI-Tn-5B1-4) cells under license from the Boyce Thompson Institute for Plant Research, Inc.

Additional Information

Source:
(BTI-Tn-5B1-4) Hi-5 Insect cells*
Purity:
Above 95% as determined by SDS-PAGE Analysis.
Cross Reactivity:
NULL
Biological Activity
Determined by its ability to inhibit IGF-II induced proliferation of human MCF-7 cells. The expected ED50 for this effect is 0.1 – 0.4 μg/ml.
AA Sequence
RCPGCGQGV QAGCPGGCV EEEDGGSPA EGCAEAEGC LRREGQECG VYTPNCAPG LQCHPPKDD EAPLRALLL GRGRCLPAR APAVAEENP KESKPQAGT ARPQDVNRR DQQRNPGTS TTPSQPNSA GVQDTEMGP CRRHLDSVL QQLQTEVYR GAQTLYVPN CDHRGFYRK RQCRSSQGQ RRGPCWCVD RMGKSLPGS PDGNGSSSC PTGSSG
Research Interest: Apoptosis, Cancer, Proliferation and Cell Cycle, Metabolic Regulation and Diabetes
Application: FA
Protein Cross Reactivity: NULL
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