Recombinant Human IGF-BP3
Catalog Number : 100-08
IGF-BP3 is a 30 kDa cysteine-rich secreted protein. It is the major IGF binding protein present in the plasma of human and animals and it is also found in α-granules of platelets. In addition to its ability to modulate the activity of IGF-I and IGF-II, IGF-BP3 exerts inhibitory effects on follicle stimulating hormone (FSH) activity. Decreased plasma levels of IGF-BP3 often results in dwarfism, whereas elevated levels of IGF-BP3 may lead to acromegaly. The expression of IGF-BP3 in fibroblasts is stimulated by mitogenic growth factors such as Bombesin, Vasopressin, PDGF, and EGF. Recombinant human IGF-BP3 is a 28.8 kDa protein consisting of 264 amino acid residues.
Above 98% as determined by SDS-PAGE Analysis.
The ED50 was determined by its ability to inhibit IGF-II induced proliferation of MCF-7. The expected ED50 for this effect is ≤ 0.2 µg/ml in presence of 15 ng/ml of human IGF-II.
GASSGGLGP VVRCEPCDA RALAQCAPP PAVCAELVR EPGCGCCLT CALSEGQPC GIYTERCGS GLRCQPSPD EARPLQALL DGRGLCVNA SAVSRLRAY LLPAPPAPG NASESEEDR SAGEVESPS VSSTHRVSD PKFHPLHSK IIIIKKGHA KDSQRYKVD YESQSTDTQ NFSSESKRE TEYGPCRRE MEDTLNHLK FLNVLSPRG VHIPNCDKK GFYKKKQCR PSKGRKRGF CWCVDKYGQ PLPGYTTKG KEDVHCYSM QSK
|Research Interest:||Apoptosis, Cancer, Proliferation and Cell Cycle, Metabolic Regulation and Diabetes|
|Protein Cross Reactivity:||NULL|