Recombinant Human FGF-23
Catalog Number : 100-52
The FGF family plays a central role during prenatal development and postnatal growth and regeneration of a variety of tissues, by promoting cellular proliferation and differentiation. FGF-23, FGF-21 and FGF-19 constitute an atypical FGF subfamily whose ligands act as circulating hormones and require the participation of a Klotho protein as a co-receptor for their signaling. FGF-23 is a bone-derived hormone that acts in the kidney to regulate phosphate homeostasis and vitamin D metabolism. The signaling receptor for FGF-23, a Klotho-FGFR1 (IIIc) complex, is an essential regulator of the renal sodium phosphate co-transporter and key vitamin D-metabolizing enzymes CYP27B1 and CYP24A1. Recombinant human FGF-23 is a 22.5 kDa globular protein containing 228 amino acid residues.
Above 95% as determined by SDS-PAGE Analysis.
Testing in Progress.
MYPNASPLL GSSWGGLIH LYTATARNS YHLQIHKNG HVDGAPHQT IYSALMIRS EDAGFVVIT GVMSRRYLC MDFRGNIFG SHYFDPENC RFQHQTLEN GYDVYHSPQ YHFLVSLGR AKRAFLPGM NPPPYSQFL SRRNEIPLI HFNTPIPRR HTRSAEDDS ERDPLNVLK PRARMTPAP ASCSQELPS AEDNSPMAS DPLGVVRGG RVNTHAGGT GPEGCRPFA KFI
|Research Interest:||Stem Cell Research, Angiogenesis, Bone Biology, Proliferation and Cell Cycle, Metabolic Regulation and Diabetes|
|Cell Type:||Stem Cells|
|Protein Cross Reactivity:||NULL|