Recombinant Human FGF-18
Catalog Number : 100-28
FGF-18 is a heparin binding growth factor that belongs to the FGF family. Proteins of this family play a central role during prenatal development and postnatal growth and regeneration of a variety of tissues, by promoting cellular proliferation and differentiation. FGF-18 is an essential regulator of long bone and calvarial development. FGF-18 signals through FGFR 1c, 2c, 3c, and 4. Recombinant E.coli derived human FGF-18 is a 20.1 kDa protein consisting of 173 amino acid residues, resulting from c-terminal truncation of the full length protein.
Above 95% as determined by SDS-PAGE Analysis.
The ED50 as determined by the dose-dependent stimulation of thymidine uptake by BaF3 cells expressing FGF-receptors is ≤ 0.5 ng/ml, corresponding to a specific activity of ≥ 2 x 106 units/mg.
AEENVDFRI HVENQTRAR DDVSRKQLR LYQLYSRTS GKHIQVLGR RISARGEDG DKYAQLLVE TDTFGSQVR IKGKETEFY LCMNRKGKL VGKPDGTSK ECVFIEKVL ENNYTALMS AKYSGWYVG FTKKGRPRK GPKTRENQQ DVHFMKRYP KGQPELQKP FKYTTVTKR SR
|Research Interest:||Stem Cell Research, Angiogenesis, Bone Biology, Proliferation and Cell Cycle|
|Protein Cross Reactivity:||Mouse, Rat|