Recombinant Human GDF-5 (BMP-14/CDMP-1)

Grouped product items
SizePrice Qty
10µg
$80.00
50µg
$195.00
100µg
$300.00
500µg
$900.00
1mg
$1,500.00
Catalog Number : 120-01

description

GDF-5 is expressed in long bones during embryonic development and postnatally in articular cartilage. Mutations in the GDF-5 gene have been implicated in Hunter-Thompson type dwarfism and in Grebe Syndrome, which is characterized by short stature, extra digits, and short and deformed extremities. The mature and functional form of GDF-5 is a homodimer of two 120 amino-acid polypeptide chain (monomers) linked by a single disulfide bond. Each GDF-5 monomer is expressed as the C-terminal part of a precursor polypeptide, which also contains a 27 amino acid signal peptide and a 354 amino acid propeptide. This precursor undergoes intracellular dimerization, and upon secretion it is processed by a furin-type protease. Recombinant Human GDF-5 is a 27.0 kDa homodimeric disulfide-linked protein consisting of two 120 amino acid polypeptide chains.

Additional Information

Source:
E. Coli
Purity:
Above 98% as determined by SDS-PAGE Analysis.
Cross Reactivity:
Mouse
Biological Activity
The ED50 was determined by its ability to induce alkaline phosphatase production by ATDC-5 chondrogenic cells is 1.0-2.0 µg/ml.
AA Sequence
APLATRQGK RPSKNLKAR CSRKALHVN FKDMGWDDW IIAPLEYEA FHCEGLCEF PLRSHLEPT NHAVIQTLM NSMDPESTP PTCCVPTRL SPISILFID SANNVVYKQ YEDMVVESC GCR
Research Interest:Stem Cell Research
Cell Type:Stem Cells
Application:FA
Protein Cross Reactivity:Mouse
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