Recombinant Human BMP-5
Catalog Number : 120-39
TGF-β family members are key modulators of cell proliferation, differentiation, matrix synthesis, and apoptosis. As implied by their name, BMPs initiate, promote, and regulate the development, growth and remodeling of bone and cartilage. In addition to this role, BMPs are also involved in prenatal development and postnatal growth, remodeling and maintenance of a variety of other tissues and organs. BMP-5 is expressed in the nervous system, lung and liver. It is a known regulator for dendritic growth in sympathetic neurons. BMP-5 is a 454 amino acid precursor protein that is cleaved to release the biologically active C-terminal mature protein. Recombinant human BMP-5 is a 15.6 kDa homodimeric disulfide-linked protein consisting of two identical 138 amino acid chains.
Above 95% as determined by SDS-PAGE Analysis.
Determined by its ability to induce alkaline phosphatase production by ATDC-5 cells. The expected ED50 for this effect is 0.5-1.0 μg/ml.
AANKRKNQN RNKSSSHQD SSRMSSVGD YNTSEQKQA CKKHELYVS FRDLGWQDW IIAPEGYAA FYCDGECSF PLNAHMNAT NHAIVQTLV HLMFPDHVP KPCCAPTKL NAISVLYFD DSSNVILKK YRNMVVRSC GCH
|Research Interest:||Apoptosis, Neurosciences, Bone Biology, Proliferation and Cell Cycle|
|Protein Cross Reactivity:||NULL|