Recombinant Human BMP-13/CDMP-2

Grouped product items
Size Price Qty
10µg
$80.00
50µg
$195.00
100µg
$300.00
500µg
$900.00
1mg
$1,500.00
Catalog Number : 120-04

description

BMP-13 is expressed in hypertrophic chondrocytes during embryonic development of long bones. Continued postnatal expression of BMP-13 in articular cartilage suggests that it plays a regulatory role in the growth and maintenance of articular cartilage. Adenovirus-mediated BMP-13 gene transfer to rabbit bone marrow stem cells have been reported to augment periosteal repair of osteochondral defects. The functional form of BMP-13/CDMP-2 is a disulfide-linked homodimer of two 120 amino acid polypeptide chains. This 27.5 kDa protein is obtained by proteolytic processing of a biologically inactive precursor protein of 97.7 kDa. Recombinant human BMP-13/CDMP-2 is a 27.0 kDa homodimeric disulfide-linked protein consisting of two 120 amino acid polypeptide chains.

Additional Information

Source:
E. Coli
Purity:
Above 95% as determined by SDS-PAGE Analysis.
Cross Reactivity:
Mouse
Biological Activity
The ED50 was determined by its ability to induce alkaline phosphatase production by ATDC-5 chondrogenic cells in the range of 2.0-3.0 µg/ml.
AA Sequence
TAFASRHGK RHGKKSRLR CSKKPLHVN FKELGWDDW IIAPLEYEA YHCEGVCDF PLRSHLEPT NHAIIQTLM NSMDPGSTP PSCCVPTKL TPISILYID AGNNVVYKQ YEDMVVESC GCR
Research Interest: Stem Cell Research, Apoptosis, Angiogenesis, Bone Biology, Proliferation and Cell Cycle
Application: FA
Protein Cross Reactivity: Mouse
© BioGems International, Inc. All rights reserved.