Recombinant Human BMP-10

Grouped product items
SizePrice Qty
2µg
$80.00
10µg
$195.00
100µg
$780.00
500µg
$2,340.00
1mg
$3,900.00
Catalog Number : 120-40

description

Bone morphogenetic proteins (BMPs) constitute a subfamily within the TGF-β superfamily of structurally related signaling proteins. Members of this superfamily are widely distributed throughout the body and are involved in diverse physiological processes during both pre- and postnatal life.  BMP-10 plays a crucial role in the development of the embryonic heart by acting to stimulate and maintain cardiomyocyte proliferation.  It can signal through various receptor complexes usually containing BMPR-1A, BMPR-1B, ALK1, ALK3, or ALK6. The interaction of BMP-10 with its specific receptors can induce signaling initiated by the phosphorylation of SMAD transcription factors, including SMAD1, SMAD5, or SMAD8, but can also induce SMAD independent processes.  BMP-10 is structurally related to BMP-9, and both can inhibit endothelial cell proliferation and migration.  Recombinant human BMP-10 is a 24.4 kDa homodimeric disulfide-linked protein consisting of two 108 amino acid subunits, which correspond to amino acid residues 317 to 424 of the full-length BMP-10 precursor.

Additional Information

Source:
HEK293 cells
Purity:
Above 95% as determined by SDS-PAGE Analysis.
Cross Reactivity:
NULL
Biological Activity
Determined by its ability to induce alkaline phosphatase production by ATDC-5 cells.  The expected ED50 for this effect is 4.0-6.0 ng/ml.
AA Sequence
NAKGNYCKR TPLYIDFKE IGWDSWIIA PPGYEAYEC RGVCNYPLA EHLTPTKHA IIQALVHLK NSQKASKAC CVPTKLEPI SILYLDKGV VTYKFKYEG MAVSECGCR
Research Interest:Stem Cell Research, Apoptosis, Angiogenesis, Bone Biology, Proliferation and Cell Cycle
Application:FA
Protein Cross Reactivity:NULL
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