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Recombinant Human MIP-1β (CCL4)



Catalog Number : 300-09

Description

Both MIP-1α and MIP-1β are structurally and functionally related CC chemokines. They participate in the host response to invading bacterial, viral, parasite and fungal pathogens by regulating the trafficking and activation state of selected subgroups of inflammatory cells e.g. macrophages, lymphocytes and NK cells. While both MIP-1α and MIP-1β exert similar effects on monocytes their effect on lymphocytes differ; with MIP-1α selectively attracting CD8+ lymphocytes and MIP-1β selectively attracting CD4+ lymphocytes. Additionally, MIP-1α and MIP-1β have also been shown to be potent chemoattractants for B cells, eosinophils and dendritic cells. Both human and murine MIP-1α and MIP-1β are active on human and murine hematopoietic cells. Recombinant human MIP-1βis a 7.6 kDa protein containing 69 amino acid residues, including the four highly conserved cysteine residues present in CC chemokines.

Additional Information

Source:
E. Coli
 
Purity:
Above 98% as determined by SDS-PAGE Analysis.
 
Cross Reactivity:
Hamster, Monkey, Mouse, Rat
 
Biological Activity
Determined by its ability to chemoattract human blood monocytes using a concentration range of 5.0-20.0 ng/ml.
 
AA Sequence
APMGSDPPT ACCFSYTAR KLPHNFVVD YYETSSLCS QPAVVFQTK RGKQVCADP SESWVQEYV YDLELN
Research Interest: Immunology, Neurosciences, Inflammation, Chemotaxis
Cell Type: Monocytes and Macrophages, NK and NKT Cells
Protein Cross Reactivity: Hamster, Monkey, Mouse, Rat

Availability: In stock

Size Price Qty
2µg
$80.00
10µg
$195.00
100µg
$600.00
500µg
$1,800.00
1mg
$3,000.00