Animal-Free Recombinant Human/Murine/Rat Activin A (E.coli-derived)
Catalog Number : AF-120-14E
description
Activin A is a TGF-β family member that exhibits a wide range of biological activities including regulation of cellular proliferation and differentiation, and promotion of neuronal survival. Elevated levels of Activin A in human colorectal tumors and in postmenopausal women have been implicated in colorectal and breast cancers, respectively. The biological activities of Activin A can be neutralized by inhibins and by the diffusible TGF-β antagonist, follistatin. Human/Murine/Rat Activin A is a 26.0 kDa disulfide-linked homodimer of two βA chains, each containing 116 amino acid residues. Manufactured using all non-animal reagents.
Additional Information
Source: | E. Coli |
Purity: | Above 97% as determined by SDS-PAGE Analysis. |
Cross Reactivity: | Chicken, Dog, Frog, Mouse, Human + Mouse |
Biological Activity | The ED50 as determined by its ability to inhibit the proliferation of murine MPC-11 cells is ≤ 2.0 ng/ml, corresponding to a specific activity of ≥ 5 x 105 units/mg. |
AA Sequence | GLECDGKVN ICCKKQFFV SFKDIGWND WIIAPSGYH ANYCEGECP SHIAGTSGS SLSFHSTVI NHYRMRGHS PFANLKSCC VPTKLRPMS MLYYDDGQN IIKKDIQNM IVEECGCS |
| Research Interest: | Cancer, Angiogenesis, Neurosciences, Proliferation and Cell Cycle |
|---|---|
| Application: | FA |
| Protein Cross Reactivity: | Chicken, Dog, Frog, Mouse, Human + Mouse |