Animal-Free Recombinant Rat TPO
TPO is a lineage specific growth factor, produced in the liver, kidney and skeletal muscle. It stimulates the proliferation and maturation of megakaryocytes, and promotes increased circulating levels of platelets in vivo. TPO signals through the c-mpl receptor and acts as an important regulator of circulating platelets. Human and murine TPO exhibits cross-species reactivity. Recombinant rat TPO is a fully biologically active 174 amino acid polypeptide (18.7 kDa), which contains the erythropoietin-like domain of the full length TPO protein. Manufactured using all non-animal reagents.
Above 98% as determined by SDS-PAGE Analysis.
Determined by its ability to stimulate the proliferation of human MO7e cells. The expected B>ED50 is ≤ 0.2 ng/ml, corresponding to a specific activity of ≥ 5 x 106 units/mg.
SPVPPACDP RLLNKLLRD SYLLHSRLS QCPDVNPLS IPVLLPAVD FSLGEWKTQ TEQSKAQDI LGAVSLLLE GVMAARGQL EPSCLSSLL GQLSGQVRL LLGALQGLL GTQLPPQGR TTAHKDPSA LFLSLQQLL RGKVRFLLL VEGPALCVR RTLPTTAVP SRTSQLLTL NKF
|Research Interest:||Stem Cell Research, Proliferation and Cell Cycle|
|Protein Cross Reactivity:||Human|