Animal-Free Recombinant Human TWEAK

Grouped product items
SizePrice Qty
25µg
$215.00
100µg
$660.00
500µg
$1,980.00
1mg
$3,300.00
Catalog Number : AF-310-06

description

TWEAK belongs to the TNF family of ligands and signals through TWEAKR also known as TNFRSF12A. TWEAK is expressed in a variety of tissues, including the adult heart, pancreas, skeletal muscle, small intestine, spleen and peripheral blood lymphocytes. TWEAK has the ability to induce NFkB activation and chemokine secretion, and to exert an apoptotic activity in certain cells, such as HT-29 human adenocarcinoma cells when cultured in the presence of IFN-γ. TWEAK also promotes proliferation and migration of endothelial cells. Recombinant human TWEAK is a soluble 17.0 kDa polypeptide (154 amino acid residues) comprising the TNF homologous region of TWEAK and is generated by proteolytic processing of the full length membrane anchored TWEAK protein. Manufactured using all non-animal reagents.

Additional Information

Source:
E. Coli
Purity:
Above 98% as determined by SDS-PAGE Analysis.
Cross Reactivity:
Mouse
Biological Activity
Assay #1: The ED50 as determined by the dose-dependent stimulation of IL-8 production by Human PBMC is less than 10 ng/ml.
Assay #2: TWEAK weakly induces the death of HT29 cells when cul
AA Sequence
MKGRKTRAR RAIAAHYEV HPRPGQDGA QAGVDGTVS GWEEARINS SSPLRYNRQ IGEFIVTRA GLYYLYCQV HFDEGKAVY LKLDLLVDG VLALRCLEE FSATAASSL GPQLRLCQV SGLLALRPG SSLRIRTLP WAHLKAAPF LTYFGLFQV H
Research Interest:Apoptosis, Angiogenesis, Neurosciences, Inflammation, Proliferation and Cell Cycle
Cell Type:B Cells, Macrophage / Monocyte, T Cells, Endothelial Cells
Application:FA
Protein Cross Reactivity:Mouse
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