Animal-Free Recombinant Human BDNF

Grouped product items
SizePrice Qty
10µg
$215.00
100µg
$1,140.00
500µg
$3,420.00
1mg
$5,700.00
Catalog Number : AF-450-02

description

BDNF is a member of the NGF family of neurotrophic growth factors. Like other members of this family, BDNF supports neuron proliferation and survival. BDNF can bind to a low affinity cell surface receptor called LNGFR, which also binds other neurotrophins such as NGF, NT-3 and NT-4. However, BDNF mediates its neurotrophic properties by signaling through a high affinity cell surface receptor called gp145/trkB. BDNF is expressed as the C-terminal portion of a 247 amino acid polypeptide precursor, which also contains a signal sequence of 18 amino acid residue and a propeptide of 110 amino acid residues. Recombinant human BDNF is a 27.0 kDa homodimer of two 120 amino acid subunits linked by strong non-covalent interactions. Human and Mouse BDNF sequences are identical. Manufactured using all non-animal reagents.

Additional Information

Source:
E. Coli
Purity:
Above 98% as determined by SDS-PAGE Analysis.
Cross Reactivity:
Chicken, Frog, Guinea Pig, Hamster, Monkey, Mouse, Rat
Biological Activity
Determined by its ability to stimulate the proliferation of rat C6 cells. The expected ED50 for this effect is 0.5-1.0 μg/ml.
AA Sequence
MHSDPARRG ELSVCDSIS EWVTAADKK TAVDMSGGT VTVLEKVPV SKGQLKQYF YETKCNPMG YTKEGCRGI DKRHWNSQC RTTQSYVRA LTMDSKKRI GWRFIRIDT SCVCTLTIK RGR
Research Interest:Stem Cell Research, Neurosciences, Proliferation and Cell Cycle
Cell Type:Neurons
Application:FA
Protein Cross Reactivity:Chicken, Frog, Guinea Pig, Hamster, Monkey, Mouse, Rat
© BioGems International, Inc. All rights reserved.