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Recombinant Murine TRAIL



Catalog Number : 315-19

Description

TRAIL is a cytotoxic protein, which activates rapid apoptosis in tumor cells, but not in normal cells. TRAIL induced apoptosis is achieved through binding to two death-signaling receptors, DR4 and DR5. These receptors belong to the TNFR superfamily of transmembrane proteins and contain a cytoplasmic “death domain”, which activates the cell’s apoptotic machinery. Recombinant murine TRAIL is a 174 amino acid polypeptide (20.0 kDa), consisting of the TNF homologous portion of the extracellular domain of the full length TRAIL protein.

Additional Information

Source:
E. Coli
 
Purity:
Above 95% as determined by SDS-PAGE Analysis.
 
Cross Reactivity:
Human
 
Biological Activity
Assay#1:Determined by the dose-dependent stimulation of MIP-2 production by mouse spleen cells using a concentration range of 10-100 ng/ml.

Assay#2:Measured by its ability to induce apoptosis in LN-18 cells
 
AA Sequence
MRGGRPQKV AAHITGITR RSNSALIPI SKDGKTLGQ KIESWESSR KGHSFLNHV LFRNGELVI EQEGLYYIY SQTYFRFQE AEDASKMVS KDKVRTKQL VQYIYKYTS YPDPIVLMK SARNSCWSR DAEYGLYSI YQGGLFELK KNDRIFVSV TNEHLMDLD QEASFFGAF LIN
Research Interest: Apoptosis
Protein Cross Reactivity: Human

Availability: In stock

Size Price Qty
10µg
$80.00
50µg
$195.00
100µg
$300.00
500µg
$900.00
1mg
$1,500.00