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Recombinant Murine IL -22



Catalog Number : 210-22

Description

IL-22 is a member of the IL-10 family of regulatory cytokines which includes IL-10, IL-19, IL-20, IL-22, IL-24 and IL-26. Members of this family share partial homology in their amino acid sequences, but they are dissimilar in their biological functions. Produced by T lymphocytes, IL-22 inhibits IL-4 production by Th2 cells, and induces acute phase reactants in the liver and pancreas. IL-22 signals through a receptor system consisting of IL-10R-β/CRF2-4 and IL-22R, both of which are members of the class II cytokine-receptor family. Recombinant murine IL-22 is a 33.4 kDa non-disulfide-linked homodimeric protein containing of two 146 amino acid polypeptide chains.

Additional Information

Source:
E. Coli
 
Purity:
Above 98% as determined by SDS-PAGE Analysis.
 
Cross Reactivity:
NULL
 
Biological Activity
Assay#1: Determined by its ability to activate STAT following receptor ligand interaction.
Assay#2: Measured by its ability to induce IL-10 secretion in COLO 205 (human colon carcinoma cells). The expected ED
 
AA Sequence
MLPVNTRCK LEVSNFQQP YIVNRTFML AKEASLADN NTDVRLIGE KLFRGVSAK DQCYLMKQV LNFTLEDVL LPQSDRFQP YMQEVVPFL TKLSNQLSS CHISGDDQN IQKNVRRLK ETVKKLGES GEIKAIGEL DLLFMSLRN ACV
Research Interest: Adaptive Immunity
Cell Type: T Cells
Protein Cross Reactivity: NULL

Availability: In stock

Size Price Qty
2µg
$80.00
10 ug
$80.00
100 ug
$215.00
500µg
$3,120.00
1mg
$5,200.00