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Recombinant Murine IL-17 (IL-17A)



Catalog Number : 210-17

Description

The originally described IL-17 protein, now known as IL-17A, is a disulfide linked homodimer, secreted by activated T-cells that act on stromal cells to induce production of proinflammatory and hematopoietic bioactive molecules. Today, IL-17 represents a family of structurally-related cytokines that share a highly conserved C-terminal region but differ from one another in their N-terminal regions and in their distinct biological roles. The six known members of this family, IL-17A through IL-17F, are secreted as homodimers. IL-17A exhibits cross-species bioactivity between human and murine cells. Recombinant murine IL-17A is a 30.0 kDa disulfide-linked homodimer of two 133 amino acid polypeptide chains.

Additional Information

Source:
E. Coli
 
Purity:
Above 98% as determined by SDS-PAGE Analysis.
 
Cross Reactivity:
Rat
 
Biological Activity
Measured by its ability to induce IL-6 production by NIH 3T3 cells.
 
AA Sequence
AAIIPQSSA CPNTEAKDF LQNVKVNLK VFNSLGAKV SSRRPSDYL NRSTSPWTL HRNEDPDRY PSVIWEAQC RHQRCVNAE GKLDHHMNS VLIQQEILV LKREPESCP FTFRVEKML VGVGCTCVA SIVRQAA
Research Interest: Adaptive Immunity, Immunology, Angiogenesis, Inflammation
Cell Type: T Cells
Protein Cross Reactivity: Rat

Availability: In stock

Size Price Qty
5µg
$80.00
25µg
$195.00
100µg
$600.00
500µg
$1,800.00
1mg
$3,000.00