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Recombinant Murine IL-10



Catalog Number : 210-10

Description

IL-10 is an immunosuppressive cytokine produced by a variety of mammalian cell types including macrophages, monocytes, T cells, B cells and keratinocytes. IL-10 inhibits the expression of proinflammatory cytokines such as IL-1 and TNFα. Like IL-4, IL-10 enhances humoral immune responses and attenuates cell-mediated immune reactions. Human IL-10 active on murine cells, but murine IL-10 is inactive on human cells. Recombinant murine IL-10 is an 18.7 kDa protein of 161 amino acid residues.

Additional Information

Source:
E. Coli
 
Purity:
Above 98% as determined by SDS-PAGE Analysis.
 
Cross Reactivity:
Human
 
Biological Activity
PeproTech's murine IL-10 is fully biologically active as measured by the dose-dependent co-stimulation (with IL-4) of the proliferation of murine MC/9 cells. The ED50 was found to be < 2 ng/ml, corresponding to a specific activity of > 5
 
AA Sequence
MSRGQYSRE DNNCTHFPV GQSHMLLEL RTAFSQVKT FFQTKDQLD NILLTDSLM QDFKGYLGC QALSEMIQF YLVEVMPQA EKHGPEIKE HLNSLGQKL KTLRMRLRR CHRFLPCEN KSKAVEQVK SDFNKLEDQ GVYKAMNEF DIFINCIEA YMMIKMKS
Research Interest: Innate Immunity, Stem Cell Research, Immunology, Cancer, Neurosciences, Inflammation
Cell Type: B Cells, Monocytes and Macrophages, T Cells, Treg cells
Protein Cross Reactivity: Human

Availability: In stock

Size Price Qty
2µg
$80.00
10µg
$195.00
100µg
$1,040.00
500µg
$3,120.00
1mg
$5,200.00