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Recombinant Murine IFN-γ



Catalog Number : 315-05

Description

IFN-γ is an acid-labile interferon produced by CD4 and CD8 T lymphocytes as well as activated NK cells. IFN-γ receptors are present in most immune cells, which respond to IFN-γ signaling by increasing the surface expression of class I MHC proteins. This promotes the presentation of antigen to T-helper (CD4+) cells. IFN-γ signaling in antigen-presenting cells and antigen-recognizing B and T lymphocytes regulates the antigen-specific phases of the immune response. Additionally, IFN-γ stimulates a number of lymphoid cell functions including the anti-microbial and anti-tumor responses of macrophages, NK cells, and neutrophils. Human IFN-γ species-specific and is biologically active only in human and primate cells. Recombinant murine IFN-γ is a 15.6 kDa protein containing 134 amino acid residues.

Additional Information

Source:
E. Coli
 
Purity:
Above 98% as determined by SDS-PAGE Analysis.
 
Cross Reactivity:
Rabbit, Rat
 
Biological Activity
Determined by its ability to inhibit the proliferation of murine WEHI-279 cells. The expected ED50 is ≤ 0.2 ng/ml, corresponding to a specific activity of ≥ 5 x 106 units/mg.
 
AA Sequence
MHGTVIESL ESLNNYFNS SGIDVEEKS LFLDIWRNW QKDGDMKIL QSQIISFYL RLFEVLKDN QAISNNISV IESHLITTF FSNSKAKKD AFMSIAKFE VNNPQVQRQ AFNELIRVV HQLLPESSL RKRKRSRC
Research Interest: Innate Immunity, Stem Cell Research, Immunology, Cancer, Angiogenesis, Neurosciences, Metabolic Regulation and Diabetes
Cell Type: B Cells, Monocytes and Macrophages, NK and NKT Cells, T Cells, Treg cells
Protein Cross Reactivity: Rabbit, Rat

Availability: In stock

Size Price Qty
20µg
$80.00
100µg
$195.00
250µg
$385.00
500µg
$660.00
1mg
$1,100.00