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Recombinant Murine HGF



Catalog Number : 315-23

Description

HGF is a mesenchymally derived potent mitogen for mature parenchymal hepatocyte cells and acts as a growth factor for a broad spectrum of tissues and cell types. HGF signals through a transmembrane tyrosine kinase receptor known as MET. Activities of HGF include induction of cell proliferation, motility, morphogenesis, inhibition of cell growth, and enhancement of neuron survival. HGF is a crucial mitogen for liver regeneration processes, especially after partial hepatectomy and other liver injuries. Human and murine HGF are cross-reactive. Murine HGF is expressed as a linear 728 amino acid polypeptide precursor glycoprotein. Proteolytic processing of this precursor generates the biologically active form of HGF, which consists of two polypeptide chains (α-chain and β-chain) held by a single disulfide bond resulting in formation of a biologically active heterodimer. The α-chain consists of 463 amino acid residues and four kringle domains. The β-chain consists of 233 amino acid residues. *Manufactured using (BTI-Tn-5B1-4) cells under license from the Boyce Thompson Institute for Plant Research, Inc.

Additional Information

Source:
(BTI-Tn-5B1-4) Hi-5 Insect cells*
 
Purity:
Above 95% as determined by SDS-PAGE Analysis.
 
Cross Reactivity:
NULL
 
Biological Activity
Determined by the dose-dependent stimulation of the proliferation of mouse IMCD3 cells using a concentration range of 10-20 ng/ml.
 
AA Sequence
Alphac hain: QKKRRNTLH EFKKSAKTT LTKEDPLLK IKTKKVNSA DECANRCIR NRGFTFTCK AFVFDKSRK RCYWYPFNS MSSGVKKGF GHEFDLYEN KDYIRNCII GKGGSYKGT VSITKSGIK CQPWNSMIP HEHSFLPSS YRGKDLQEN YCRNPRGEE GGPWCFTSN PEVRYEVCD IPQCSEVEC MTCNGESYR GPMDHTESG KTCQRWDQQ TPHRHKFLP ERYPDKGFD DNYCRNPDG KPRPWCYTL DPDTPWEYC AIKTCAHSA VNETDVPME TTECIQGQG EGYRGTSNT IWNGIPCQR WDSQYPHKH DITPENFKC KDLRENYCR NPDGAESPW CFTTDPNIR VGYCSQIPK CDVSSGQDC YRGNGKNYM GNLSKTRSG LTCSMWDKN MEDLHRHIF WEPDASKLN KNYCRNPDD DAHGPWCYT GNPLIPWDY CPISRCEGD TTPTIVNLD HPVISCAKT KQLR
Betach ain:V VNGIPTQTT VGWMVSLKY RNKHICGGS LIKESWVLT ARQCFPARN KDLKDYEAW LGIHDVHER GEEKRKQIL NISQLVYGP EGSDLVLLK LARPAILDN FVSTIDLPS YGCTIPEKT TCSIYGWGY TGLINADGL LRVAHLYIM GNEKCSQHH QGKVTLNES ELCAGAEKI GSGPCEGDY GGPLICEQH KMRMVLGVI VPGRGCAIP NRPGIFVRV AYYAKWIHK VILTYKL
Research Interest: Stem Cell Research
Protein Cross Reactivity: NULL

Availability: In stock

Size Price Qty
5µg
$80.00
20µg
$195.00
100µg
$780.00
500µg
$2,340.00
1mg
$3,900.00