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Recombinant Murine GDNF



Catalog Number : 450-44

Description

GDNF is a disulfide-linked homodimeric neurotrophic factor structurally related to Artemin, Neurturin and Persephin. These proteins belong to the cysteine-knot superfamily of growth factors that assume stable dimeric protein structures. GDNF signals through a multicomponent receptor system, composed of a RET and one of the four GFR α(α1-α4) receptors. GDNF specifically promotes dopamine uptake and survival and morphological differentiation of midbrain neurons. Using Parkinson’s disease mouse model, GDNF has been shown to improve conditions such as bradykinesia, rigidity, and postural instability. The functional murine GDNF ligand is a disulfide-linked homodimer, of two 15.1 kDa polypeptide chains called monomers. Each monomer contains seven conserved cysteine residues, one of which is used for inter-chain disulfide bridging and the others are involved in intramolecular ring formation known as the cysteine knot configuration.

Additional Information

Source:
E. Coli
 
Purity:
Above 98% as determined by SDS-PAGE Analysis.
 
Cross Reactivity:
Rat
 
Biological Activity
The ED50 was determined by the proliferation of rat C6 cells is ≤ 0.2 ng/ml, corresponding to a specific activity of ≥ 5 x 106 units/mg.
 
AA Sequence
MSPDKQAAA LPRRERNRQ AAAASPENS RGKGRRGQR GKNRGCVLT AIHLNVTDL GLGYETKEE LIFRYCSGS CESAETMYD KILKNLSRS RRLTSDKVG QACCRPVAF DDDLSFLDD NLVYHILRK HSAKRCGCI
Research Interest: Stem Cell Research, Angiogenesis, Neurosciences
Cell Type: Stem Cells, Neurons
Protein Cross Reactivity: Rat

Availability: In stock

Size Price Qty
2µg
$80.00
10µg
$195.00
100µg
$1,040.00
500µg
$3,120.00
1mg
$5,200.00