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Recombinant Murine GDF-5 (BMP-14/CDMP-1)



Catalog Number : 315-24

Description

GDF-5 is expressed in long bones during embryonic development and postnatally in articular cartilage. Mutations in the GDF-5 gene have been implicated in Grebe Syndrome, which is characterized by short stature, extra digits, short and deformed extremities, and in Hunter-Thompson type dwarfism. The mature and functional form of GDF-5 is a homodimer of two 120 amino-acid polypeptide chain (monomers) linked by a single disulfide bond. Each GDF-5 monomer is expressed as the C-terminal part of a precursor polypeptide, which also contains a 27 amino-acid signal peptide and a 348 amino-acid propeptide. This precursor undergoes intracellular dimerization, and upon secretion it is processed by a furin-type protease. Recombinant murine GDF-5 is a 27.0 kDa homodimeric disulfide-linked protein consisting of two 120 amino acids.

Additional Information

Source:
E. Coli
 
Purity:
Above 98% as determined by SDS-PAGE Analysis.
 
Cross Reactivity:
NULL
 
Biological Activity
Determined by its ability to induce alkaline phosphatase production by ATDC-5 cells. The expected ED50 for this effect is 1.0-2.0 µg/ml.
 
AA Sequence
APLANRQGK RPSKNLKAR CSRKALHVN FKDMGWDDW IIAPLEYEA FHCEGLCEF PLRSHLEPT NHAVIQTLM NSMDPESTP PTCCVPTRL SPISILFID SANNVVYKQ YEDMVVESC GCR
Research Interest: Stem Cell Research
Cell Type: Stem Cells
Protein Cross Reactivity: NULL

Availability: In stock

Size Price Qty
10µg
$80.00
50µg
$195.00
100µg
$300.00
500µg
$900.00
1mg
$1,500.00