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Recombinant Murine Flt3-Ligand



Catalog Number : 250-31L

Description

Flt3-Ligand is a growth factor that regulates proliferation of early hematopoietic cells. Flt3-Ligand binds to cells expressing the tyrosine kinase receptor Flt3. Flt3-Ligand, by itself does not stimulate proliferation of early hematopoietic cells, but synergizes with other CSFs and interleukins to induce growth and differentiation. Unlike SCF, Flt3-Ligand has no activity on mast cells. Multiple isoforms of Flt3-Ligand have been identified. The predominant biologically active form is anchored to the cell surface as the extracellular domain of a transmembrane protein (209 a.a.). The membrane-bound isoform can be proteolytically cleaved to generate a biologically active soluble isoform. Recombinant murine Flt3-Ligand is a soluble 18.6 kDa protein consisting of 163 amino acid residues.

Additional Information

Source:
E. Coli
 
Purity:
Above 98% as determined by SDS-PAGE Analysis.
 
Cross Reactivity:
Human
 
Biological Activity
Determined by the dose-dependent stimulation of the proliferation of human AML5 cells. The expected ED50 for this effect is 5.0 – 8.0 ng/ml.
 
AA Sequence
MTPDCYFSH SPISSNFKV KFRELTDHL LKDYPVTVA VNLQDEKHC KALWSLFLA QRWIEQLKT VAGSKMQTL LEDVNTEIH FVTSCTFQP LPECLRFVQ TNISHLLKD TCTQLLALK PCIGKACQN FSRCLEVQC QPDSSTLLP PRSPIALEA TELPEPRPR Q
Research Interest: Stem Cell Research, Immunology, Cancer, Proliferation and Cell Cycle
Cell Type: Stem Cells
Protein Cross Reactivity: Human

Availability: In stock

Size Price Qty
2µg
$80.00
10µg
$195.00
100µg
$780.00
500µg
$2,340.00
1mg
$3,900.00