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Recombinant Murine BMP-4



Catalog Number : 315-27

Description

Bone morphogenetic proteins (BMPs) constitute a subfamily within the TGF-β superfamily of structurally related signaling proteins. Members of this superfamily are widely distributed throughout the body and are involved in diverse physiological processes during both pre- and postnatal life. Like BMP-7, BMP-4 is involved in the development and maintenance of bone and cartilage. Reduced expression of BMP-4 is associated with a number of bone diseases, including the heritable disorder Fibrodysplasia Ossificans Progressiva. The E.coli derived murine BMP-4 is a fully active homodimeric protein consisting of two 106 amino acid subunits which correspond to amino acids 303-408 of the full length BMP-4 precursor.

Additional Information

Source:
E. Coli
 
Purity:
Above 98% as determined by SDS-PAGE Analysis.
 
Cross Reactivity:
NULL
 
Biological Activity
Determined by its ability to induce alkaline phosphatase production by ATDC-5 cells. The expected ED50 for this effect is 5-15 ng/ml.
 
AA Sequence
KKNKNCRRH SLYVDFSDV GWNDWIVAP PGYQAFYCH GDCPFPLAD HLNSTNHAI VQTLVNSVN SSIPKACCV PTELSAISM LYLDEYDKV VLKNYQEMV VEGCGCRKK NKNCRRHSL YVDFSDVGW NDWIVAPPG YQAFYCHGD CPFPLADHL NSTNHAIVQ TLVNSVNSS IPKACCVPT ELSAISMLY LDEYDKVVL KNYQEMVVE GCGCR
Research Interest: Stem Cell Research, Apoptosis, Angiogenesis, Bone Biology, Proliferation and Cell Cycle
Protein Cross Reactivity: NULL

Availability: In stock

Size Price Qty
2µg
$80.00
10µg
$195.00
100µg
$780.00
500µg
$2,340.00
1mg
$3,900.00