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Recombinant Human VEGF-C



Catalog Number : 100-20C

Description

VEGF-C, a member of the VEGF/PDGF family of structurally related proteins, is a potent angiogenic cytokine. It promotes endothelial cell growth, promotes lymphangiogesis, and can also affect vascular permeability. VEGF-C is expressed in various tissues, but is not produced in peripheral blood lymphocytes. It forms cell surfaced-associated non-covalent disulfide linked homodimers, and can bind and activate both VEGFR-2 (flk1) and VEGFR-3 (flt4) receptors. During embryogenesis, VEGF-C may play a role in the formation of the venous and lymphatic vascular systems. Both VEGF-C and VEGF-D are over-expressed in certain cancers, and the resulting elevated levels of VEGF-C or VEGF-D tend to correlate with increased lymphatic metastasis. Recombinant human VEGF-C is a 13.5 kDa non-disulfide linked homodimeric protein consisting of two 116 amino acid polypeptide chains. Due to glycosylation the protein migrates as a 20.0-22.0 kDa band under non-reducing condition.

Additional Information

Source:
HEK293 cells
 
Purity:
Above 95% as determined by SDS-PAGE Analysis.
 
Cross Reactivity:
NULL
 
Biological Activity

Determined by its ability to support rat Retinal Ganglion Cells (RGC-5) cell growth in low serum media.

 
AA Sequence
MAHYNTEIL KSIDNEWRK TQCMPREVC IDVGKEFGV ATNTFFKPP CVSVYRCGG CCNSEGLQC MNTSTSYLS KTLFEITVP LSQGPKPVT ISFANHTSC RCMSKLDVY RQVHSIIRR
Research Interest: Cancer, Angiogenesis, Inflammation, Proliferation and Cell Cycle
Cell Type: Endothelial Cells
Protein Cross Reactivity: NULL

Availability: In stock

Size Price Qty
5µg
$80.00
20µg
$195.00
100µg
$600.00
500µg
$1,800.00
1mg
$3,000.00