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Recombinant Human VEGF-B



Catalog Number : 100-20B

Description

VEGF-B, a member of the VEGF family, is a potent growth and angiogenic cytokine. It promotes DNA synthesis in endothelial cells, helps regulate angiogenesis and vascular permeability, and inhibits apoptosis in certain smooth muscle cells and neurons. VEGF-B is expressed in all tissues except the liver. It forms cell surfaced-associated disulfide linked homodimers and can form heterodimers with VEGF-A. There are two known isoforms, formed by alternative splicing, which have been designated VEGF-B167 and VEGF-B186. Both forms have identical amino-terminal sequences encoding a “cysteine knot” like structural motif, but differ in their carboxyl-terminal domains. Both VEGF-B isoforms signal only through the VEGFR1 receptor. Recombinant human VEGF-B is a 38.0 kDa disulfide-linked homodimeric protein consisting of two 167 amino acid polypeptide chains.

Additional Information

Source:
E. Coli
 
Purity:
Above 98% as determined by SDS-PAGE Analysis.
 
Cross Reactivity:
NULL
 
Biological Activity
Determined by the dose-dependent stimulation of the proliferation of human umbilical vein endothelial cells (HUVEC) in the presence of human VEGF165. The expected ED50 for this effect is 1.0-2.0 μg/ml.
 
AA Sequence
PVSQPDAPG HQRKVVSWI DVYTRATCQ PREVVVPLT VELMGTVAK QLVPSCVTV QRCGGCCPD DGLECVPTG QHQVRMQIL MIRYPSSQL GEMSLEEHS QCECRPKKK DSAVKPDSP RPLCPRCTQ HHQRPDPRT CRCRCRRRS FLRCQGRGL ELNPDTCRC RKLRR
Research Interest: Cancer, Angiogenesis, Inflammation, Proliferation and Cell Cycle
Cell Type: Endothelial Cells, Neurons
Protein Cross Reactivity: NULL

Availability: In stock

Size Price Qty
5µg
$80.00
20µg
$195.00
100µg
$780.00
500µg
$2,340.00
1mg
$3,900.00