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Recombinant Human VCAM-1



Catalog Number : 150-04

Description

VCAM is a 110 kDa cell surface integral membrane glycoprotein that belongs to the Ig-related superfamily of adhesion molecules. The primary function of VCAM-1 is the mediation of leukocyte-endothelial cell adhesion and signal transduction. VCAM-1 may play a vital role in the development several diseases, including atherosclerosis and rheumatoid arthritis. The human VCAM-1 gene codes for a 715 amino acid transmembrane glycoprotein containing a 19 amino acid cytoplasmic domain, a 22 amino acid transmembrane domain, and a 674 amino acid extracellular domain. Recombinant human VCAM-1 is a 74.0kDa glycoprotein comprising the extracellular domain (674 amino acid residues) of VCAM-1. Monomeric glycosylated VCAM-1 migrates at an apparent molecular weight of approximately 90.0kDa by SDS-PAGE analysis under reducing conditions.

Additional Information

Source:
HEK293 cells
 
Purity:
Above 97% as determined by SDS-PAGE Analysis.
 
Cross Reactivity:
NULL
 
Biological Activity
Determined by its ability to support the adhesion of human U937 cells. The expected ED50 for this effect is 0.8-1.0 μg/ml.
 
AA Sequence
FKIETTPES RYLAQIGDS VSLTCSTTG CESPFFSWR TQIDSPLNG KVTNEGTTS TLTMNPVSF GNEHSYLCT ATCESRKLE KGIQVEIYS FPKDPEIHL SGPLEAGKP ITVKCSVAD VYPFDRLEI DLLKGDHLM KSQEFLEDA DRKSLETKS LEVTFTPVI EDIGKVLVC RAKLHIDEM DSVPTVRQA VKELQVYIS PKNTVISVN PSTKLQEGG SVTMTCSSE GLPAPEIFW SKKLDNGNL QHLSGNATL TLIAMRMED SGIYVCEGV NLIGKNRKE VELIVQEKP FTVEISPGP RIAAQIGDS VMLTCSVMG CESPSFSWR TQIDSPLSG KVRSEGTNS TLTLSPVSF ENEHSYLCT VTCGHKKLE KGIQVELYS FPRDPEIEM SGGLVNGSS VTVSCKVPS VYPLDRLEI ELLKGETIL ENIEFLEDT DMKSLENKS LEMTFIPTI EDTGKALVC QAKLHIDDM EFEPKQRQS TQTLYVNVA PRDTTVLVS PSSILEEGS SVNMTCLSQ GFPAPKILW SRQLPNGEL QPLSENATL TLISTKMED SGVYLCEGI NQAGRSRKE VELIIQVTP KDIKLTAFP SESVKEGDT VIISCTCGN VPETWIILK KKAETGDTV LKSIDGAYT IRKAQLKDA GVYECESKN KVGSQLRSL TLDVQGREN NKDYFSP
Research Interest: Adaptive Immunity, Angiogenesis
Cell Type: B Cells, Monocytes and Macrophages, T Cells
Protein Cross Reactivity: NULL

Availability: In stock

Size Price Qty
10µg
$80.00
50µg
$195.00
100µg
$300.00
500µg
$900.00
1mg
$1,500.00