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Recombinant Human Vaspin



Catalog Number : 130-11

Description

Vaspin is a newly described adipocytokine expressed predominantly in visceral white adipose tissues. Structure analysis of Vaspin predicts the presence of three β-sheets, nine α-helices, and one central loop, which are distinctive structural features of Serpin family members. The serpins are irreversible (“suicidal”) serine-protease inhibitors, characterized by having more than 30% sequence homology with α1-antitrypsin and a conserved tertiary structure, which contains an exposed reactive center loop that acts as a pseudo-substrate for the target proteinase. Members of this family play an important role in a number of fundamental biological processes including blood coagulation, fibrinolysis, complement activation, angiogenesis, inflammation, and tumor suppression. In human, the serpins represent approximately 2% of total serum proteins, of which 70% is α1- antitrypsin. Vaspin exhibits 40.2% sequence identity with α-1-antitrypsin. Yet, its protease inhibitory activity is still unknown. Vaspin mRNA expression in visceral fat is positively correlated with BMI and percent of body fat. Administration of Vaspin to obese mice improved glucose tolerance and insulin sensitivity, reflected by normalized blood glucose levels. It also led to the reversal of altered expression of diabetes-relevant adipocytokines including leptin, adiponectin, resistin, and TNF-α. These findings suggest a potential clinical use for Vaspin in ameliorating certain aberrations seen in the diabetic/obesity metabolic syndrome. Recombinant human Vaspin is a 45.2 kDa protein containing 395 amino-acid residues.

Additional Information

Source:
E. Coli
 
Purity:
Above 98% as determined by SDS-PAGE Analysis.
 
Cross Reactivity:
NULL
 
Biological Activity
Data Not Available.
 
AA Sequence
MLKPSFSPR NYKALSEVQ GWKQRMAAK ELARQNMDL GFKLLKKLA FYNPGRNIF LSPLSISTA FSMLCLGAQ DSTLDEIKQ GFNFRKMPE KDLHEGFHY IIHELTQKT QDLKLSIGN TLFIDQRLQ PQRKFLEDA KNFYSAETI LTNFQNLEM AQKQINDFI SQKTHGKIN NLIENIDPG TVMLLANYI FFRARWKHE FDPNVTKEE DFFLEKNSS VKVPMMFRS GIYQVGYDD KLSCTILEI PYQKNITAI FILPDEGKL KHLEKGLQV DTFSRWKTL LSRRVVDVS VPRLHMTGT FDLKKTLSY IGVSKIFEE HGDLTKIAP HRSLKVGEA VHKAELKMD ERGTEGAAG TGAQTLPME TPLVVKIDK PYLLLIYSE KIPSVLFLG KIVNPIGK
Research Interest: Angiogenesis, Inflammation, Metabolic Regulation and Diabetes
Protein Cross Reactivity: NULL

Availability: In stock

Size Price Qty
5µg
$80.00
25µg
$195.00
100µg
$600.00
500µg
$1,800.00
1mg
$3,000.00