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Recombinant Human TSLP



Catalog Number : 300-62

Description

TSLP is a hemopoietic protein that is expressed in the heart, liver and prostate. TSLP overlaps biological activities with IL-7 and binds with the heterodimeric receptor complex consisting of the IL-7R α chain (IL-7Rα) and the TSLP-specific chain (TSLPR). Like IL-7, TSLP induces phosphorylation of STAT3 and STAT5, but uses kinases other than the JAKs for activation. TSLP prohibited apoptosis and stimulated growth of the human acute myeloid leukemia (AML)-derived cell line MUTZ3. It induces the release of T cell-attracting chemokines TARC and MDC from monocytes and activates CD11c(+) dendritic cells (DCs). TSLP activated DCs primed naïve T cells to produce the proallergic cytokines (IL-4, IL-5, IL-13, TNFα) while down-regulating IL-10 and IFN-γ suggesting a role in initiating allergic inflammation. Recombinant human TSLP is a 15.0 kDa protein consisting of 132 amino acid residues.

Additional Information

Source:
E. Coli
 
Purity:
Above 98% as determined by SDS-PAGE Analysis.
 
Cross Reactivity:
NULL
 
Biological Activity
Data not available at this time.
 
AA Sequence
MYDFTNCDF EKIKAAYLS TISKDLITY MSGTKSTEF NNTVSCSNR PHCLTEIQS LTFNPTAGC ASLAKEMFA MKTKAALAI WCPGYSETQ INATQAMKK RRKRKVTTN KCLEQVSQL QGLWRRFNR PLLKQQ
Research Interest: Innate Immunity, Apoptosis, Inflammation
Cell Type: Monocytes and Macrophages, T Cells, Dendritic Cells
Protein Cross Reactivity: NULL

Availability: In stock

Size Price Qty
2µg
$80.00
10µg
$195.00
100µg
$1,040.00
500µg
$3,120.00
1mg
$5,200.00