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Recombinant Human TLR-3



Catalog Number : 160-01

Description

TLR-3 is a single-pass type I receptor that binds to and signals the presence of microbial pathogens and double stranded RNA (dsRNA) viruses. Signaling through TLR-3 can promote the NF-κB pathway to initiate innate and adaptive immune responses to bacterial and viral infections, as well as the p53 pathway to trigger apoptosis in cells infected with dsRNA viruses. TLR-3 belongs to a family of structurally-related toll-like receptors (TLRs) containing an N-terminal domain rich in leucine repeats and a C-terminal intracellular Toll/interleukin (IL)-1 (TIL) domain. TLR-3 is expressed primarily in dendritic cells of the placenta and pancreas where it can reside on both sides of the plasma membrane and in the endosomal compartment of the cells. Recombinant human TLR-3 is 77.4 kDa glycoprotein containing 681 residues which comprise the TLR-3 extracellular domain.

Additional Information

Source:
HEK293 cells
 
Purity:
Above 95% as determined by SDS-PAGE Analysis.
 
Cross Reactivity:
NULL
 
Biological Activity
Determined by its ability to inhibit IL-8 secretion induced by Poly I:C in the TLR3 receptor-expressing HEK293 cells (HEK293 TLR3r). The ED50for this effect is ≤ 30 μg/ml in the presence of 100 μg/ml of Poly I:C.
 
AA Sequence
STTKCTVSH EVADCSHLK LTQVPDDLP TNITVLNLT HNQLRRLPA ANFTRYSQL TSLDVGFNT ISKLEPELC QKLPMLKVL NLQHNELSQ LSDKTFAFC TNLTELHLM SNSIQKIKN NPFVKQKNL ITLDLSHNG LSSTKLGTQ VQLENLQEL LLSNNKIQA LKSEELDIF ANSSLKKLE LSSNQIKEF SPGCFHAIG RLFGLFLNN VQLGPSLTE KLCLELANT SIRNLSLSN SQLSTTSNT TFLGLKWTN LTMLDLSYN NLNVVGNDS FAWLPQLEY FFLEYNNIQ HLFSHSLHG LFNVRYLNL KRSFTKQSI SLASLPKID DFSFQWLKC LEHLNMEDN DIPGIKSNM FTGLINLKY LSLSNSFTS LRTLTNETF VSLAHSPLH ILNLTKNKI SKIESDAFS WLGHLEVLD LGLNEIGQE LTGQEWRGL ENIFEIYLS YNKYLQLTR NSFALVPSL QRLMLRRVA LKNVDSSPS PFQPLRNLT ILDLSNNNI ANINDDMLE GLEKLEILD LQHNNLARL WKHANPGGP IYFLKGLSH LHILNLESN GFDEIPVEV FKDLFELKI IDLGLNNLN TLPASVFNN QVSLKSLNL QKNLITSVE KKVFGPAFR NLTELDMRF NPFDCTCES IAWFVNWIN ETHTNIPEL SSHYLCNTP PHYHGFPVR LFDTSSCKD SAPFEL
Research Interest: Innate Immunity, Adaptive Immunity, Apoptosis, Receptors, Inflammation
Cell Type: Dendritic Cells
Protein Cross Reactivity: NULL

Availability: In stock

Size Price Qty
5µg
$80.00
25µg
$195.00
100µg
$600.00
500µg
$1,800.00
1mg
$3,000.00