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Recombinant Human TIMP-2



Catalog Number : 410-02

Description

TIMP-2 is an extracellular inhibitor of MMPs including MMP1, 2, 3, 7, 8, 9, 10, 12, 13, 14, 15, 16 and 19. It belongs to the I35 (TIMP) family of irreversible protease inhibitors that function as key modulators of extracellular matrix degradation during tissue development and remodeling. TIMP-2 can also act through an MMP-independent mechanism inhibiting endothelial cell proliferation in vitro and demonstrates anti-angiogenic activities in vivo. Recombinant human TIMP-2 is a 21.8 kDa protein containing 194 amino acid residues.

Additional Information

Source:
E. Coli
 
Purity:
Above 95% as determined by SDS-PAGE Analysis.
 
Cross Reactivity:
NULL
 
Biological Activity
TIMP-2 activity was measured by its ability to inhibit human MMP-1 induced hydrolysis of a chromogenic peptide substrate at room temperature. Half maximal inhibition was obtained at a TIMP-2 concentration of approximately 0.5 μg/ml, when using an MMP-1
 
AA Sequence
CSCSPVHPQ QAFCNADVV IRAKAVSEK EVDSGNDIY GNPIKRIQY EIKQIKMFK GPEKDIEFI YTAPSSAVC GVSLDVGGK KEYLIAGKA EGDGKMHIT LCDFIVPWD TLSTTQKKS LNHRYQMGC ECKITRCPM IPCYISSPD ECLWMDWVT EKNINGHQA KFFACIKRS DGSCAWYRG AAPPKQEFL DIEDP
Research Interest: Stem Cell Research, Proliferation and Cell Cycle
Protein Cross Reactivity: NULL

Availability: In stock

Size Price Qty
2µg
$80.00
10µg
$195.00
100µg
$1,040.00
500µg
$3,120.00
1mg
$5,200.00