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Recombinant Human TGF-α



Catalog Number : 100-16A

Description

TGF-α is an EGF-related polypeptide growth factor that signals through the EGF receptor, and stimulates the proliferation of a wide range of epidermal and epithelial cells. It is produced by monocytes, keratinocytes, and various tumor cells. TGF-α induces transformation anchorage independence in cultured cells. Human, murine and rat TGF-α are cross-species reactive. Recombinant human TGF-α is a 50 amino acid polypeptide (5.5 kDa) which shares approximately 40% sequence homology with EGF, including 6 conserved cysteine residues, which form 3 intramolecular disulfide bonds.

Additional Information

Source:
E. Coli
 
Purity:
Above 98% as determined by SDS-PAGE Analysis.
 
Cross Reactivity:
Chicken, Mouse, Rat
 
Biological Activity
The ED50 as determined by the dose-dependent stimulation of thymidine uptake by BALB/c 3T3 cells is ≤ 0.2 ng/ml, corresponding to a specific activity of ≥ 5 x 106 units/mg.
 
AA Sequence
VVSHFNDCP DSHTQFCFH GTCRFLVQE DKPACVCHS GYVGARCEH ADLLA
Research Interest: Cancer, Angiogenesis, Inflammation
Protein Cross Reactivity: Chicken, Mouse, Rat

Availability: In stock

Size Price Qty
20µg
$80.00
100µg
$195.00
250µg
$385.00
500µg
$660.00
1mg
$1,100.00