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Recombinant Human TGF-β1 (CHO cell derived)



Catalog Number : 100-21C

Description

The three mammalian isoforms of TGF-β, TGF-β1, β2, β3, signal through the same receptor and elicit similar biological responses. They are multifunctional cytokines that regulate cell proliferation, growth, differentiation and motility as well as synthesis and deposition of the extracellular matrix. They are involved in various physiological processes including embryogenesis, tissue remodeling and wound healing. They are secreted predominantly as latent complexes which are stored at the cell surface and in the extracellular matrix. The release of biologically active TGF-β isoform from a latent complex involves proteolytic processing of the complex and /or induction of conformational changes by proteins such as thrombospondin-1. TGF-β1 is the most abundant isoform secreted by almost every cell type. It was originally identified for its ability to induce phenotypic transformation of fibroblasts and recently it has been implicated in the formation of skin tumors. Recombinant human TGF-β1 is a 25.0 kDa protein composed of two identical 112 amino acid polypeptide chains linked by a single disulfide bond.

Additional Information

Source:
CHO cells
 
Purity:
Above 98% as determined by SDS-PAGE Analysis.
 
Cross Reactivity:
Chicken, Cow, Dog, Frog, Monkey, Mouse, Pig, Rabbit, Rat
 
Biological Activity
The ED50 was determined by TGF-β1’s ability to inhibit the mouse IL-4-dependent proliferation of mouse HT-2 cells is ≤ 0.05 ng/ml, corresponding to a specific activity of ≥ 2 x 107 units/mg
 
AA Sequence
ALDTNYCFS STEKNCCVR QLYIDFRKD LGWKWIHEP KGYHANFCL GPCPYIWSL DTQYSKVLA LYNQHNPGA SAAPCCVPQ ALEPLPIVY YVGRKPKVE QLSNMIVRS CKCS
Research Interest: Innate Immunity, Stem Cell Research, Apoptosis, Cancer, Angiogenesis, Inflammation, Proliferation and Cell Cycle
Cell Type: T Cells, Treg cells
Protein Cross Reactivity: Chicken, Cow, Dog, Frog, Monkey, Mouse, Pig, Rabbit, Rat

Availability: In stock

Size Price Qty
2µg
$80.00
10µg
$195.00
100µg
$1,200.00
500µg
$4,200.00
1mg
$7,000.00