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Recombinant Human sTRAIL Receptor-1



Catalog Number : 310-18

Description

TRAIL Receptor-1/DR4 and TRAIL Receptor-2/DR5 belong to the TNFR superfamily of transmembrane proteins and contain a cytoplasmic "death domain, " which can activate the cell's apoptotic machinery. These receptors are activated by binding to either membrane anchored or soluble TRAIL/Apo2L. Recombinant human soluble TRAIL Receptor-1/DR4 is a 22.7 kDa protein (215 amino acid residues) consisting of the TNFR homologous, cysteine rich portion of the extracellular domain.

Additional Information

Source:
E. Coli
 
Purity:
Above 98% as determined by SDS-PAGE Analysis.
 
Cross Reactivity:
NULL
 
Biological Activity
Measured by its ability to inhibit apoptosis in LN-18 cells.  The expected ED50 for this effect is 0.4 -0.5 µg/ml.
 
AA Sequence
MSGTGAAAA TPSKVWGSS AGRIEPRGG GRGALPTSM GQHGPSARA RAGRAPGPR PAREASPRL RVHKTFKFV VVGVLLQVV PSSAATIKL HDQSIGTQQ WEHSPLGEL CPPGSHRSE RPGACNRCT EGVGYTNAS QQLFACLPC TACKSDEEE RSPCTTTRN TACQCKPGT FRNDNSAEM CRKCSTGCP RGMVKVKDC TPWSDIECV HKESGNGHN
Research Interest: Receptors
Protein Cross Reactivity: NULL

Availability: In stock

Size Price Qty
10µg
$80.00
50µg
$195.00
100µg
$300.00
500µg
$900.00
1mg
$1,500.00