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Recombinant Human sFRP-1



Catalog Number : 120-29

Description

Secreted Frizzled Related Proteins (sFRPs) modulate WNT signaling by binding directly to WNT proteins in a manner that affects their receptor binding and signaling capabilities. sFRP-1 is a widely distributed protein that can bind directly to WNT1, WNT2, and possibly other WNT proteins, and generally exerts anti-proliferative effects consistent with activity as a WNT antagonist. It also inhibits apoptosis and has been found to be down-regulated in many solid tumors, but up-regulated in uterine leiomyomas. Recombinant human sFRP-1 is a glycosylated 283 amino acid protein containing a cysteine rich Frizzled homologous domain.

Additional Information

Source:
HeLa cells
 
Purity:
Above 97% as determined by SDS-PAGE Analysis.
 
Cross Reactivity:
Mouse
 
Biological Activity
Determined by its ability to inhibit BMP-2 proliferation effect of ATDC-5 cells. The expected ED50 is 0.3–0.5 μg/ml.
 
AA Sequence
SEYDYVSFQ SDIGPYQSG RFYTKPPQC VDIPADLRL CHNVGYKKM VLPNLLEHE TMAEVKQQA SSWVPLLNK NCHAGTQVF LCSLFAPVC LDRPIYPCR WLCEAVRDS CEPVMQFFG FYWPEMLKC DKFPEGDVC IAMTPPNAT EASKPQGTT VCPPCDNEL KSEAIIEHL CASEFALRM KIKEVKKEN GDKKIVPKK KKPLKLGPI KKKDLKKLV LYLKNGADC PCHQLDNLS HHFLIMGRK VKSQYLLTA IHKWDKKNK EFKNFMKKM KNHECPTFQ SVFK
Research Interest: Apoptosis, Cancer, Angiogenesis, Proliferation and Cell Cycle
Protein Cross Reactivity: Mouse

Availability: In stock

Size Price Qty
5µg
$80.00
20µg
$195.00
100µg
$780.00
500µg
$2,340.00
1mg
$3,900.00