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Recombinant Human PECAM-1



Catalog Number : 150-06

Description

PECAM is transmembrane glycoprotein that belongs to the Ig-related superfamily of adhesion molecules. It is highly expressed at endothelial cell junctions, and also expressed in platelets and in most leukocyte sub-types. The primary function of PECAM-1 is the mediation of leukocyte-endothelial cell adhesion and signal transduction. PECAM-1 has been implicated in the pathogenesis of various inflammation related disorders, including thrombosis, multiple sclerosis (MS), and rheumatoid arthritis. The human PECAM-1 gene codes for a 738 amino acid transmembrane glycoprotein containing a 118 amino acid cytoplasmic domain, a 19 amino acid transmembrane domain, and a 574 amino acid extracellular domain. Recombinant human PECAM-1 is a 572 amino acid glycoprotein comprising the extracellular domain of PECAM-1. Monomeric glycosylated PECAM-1 migrates at an apparent molecular weight of approximately 80.0-95.0 kDa by SDS-PAGE analysis under reducing conditions

Additional Information

Source:
HEK293 cells
 
Purity:
Above 97% as determined by SDS-PAGE Analysis.
 
Cross Reactivity:
NULL
 
Biological Activity
Determined by its ability to support the adhesion of activated Jurkat cells. The expected ED50 for this effect is 1.0 -1.5 μg/ml.
 
AA Sequence
ENSFTINSV DMKSLPDWT VQNGKNLTL QCFADVSTT SHVKPQHQM LFYKDDVLF YNISSMKST ESYFIPEVR IYDSGTYKC TVIVNNKEK TTAEYQLLV EGVPSPRVT LDKKEAIQG GIVRVNCSV PEEKAPIHF TIEKLELNE KMVKLKREK NSRDQNFVI LEFPVEEQD RVLSFRCQA RIISGIHMQ TSESTKSEL VTVTESFST PKFHISPTG MIMEGAQLH IKCTIQVTH LAQEFPEII IQKDKAIVA HNRHGNKAV YSVMAMVEH SGNYTCKVE SSRISKVSS IVVNITELF SKPELESSF THLDQGERL NLSCSIPGA PPANFTIQK EDTIVSQTQ DFTKIASKS DSGTYICTA GIDKVVKKS NTVQIVVCE MLSQPRISY DAQFEVIKG QTIEVRCES ISGTLPISY QLLKTSKVL ENSTKNSND PAVFKDNPT EDVEYQCVA DNCHSHAKM LSEVLRVKV IAPVDEVQI SILSSKVVE SGEDIVLQC AVNEGSGPI TYKFYREKE GKPFYQMTS NATQAFWTK QKASKEQEG EYYCTAFNR ANHASSVPR SKILTVRVI LAPWK
Research Interest: Inflammation
Cell Type: Endothelial Cells
Protein Cross Reactivity: NULL

Availability: In stock

Size Price Qty
10µg
$80.00
50µg
$195.00
100µg
$300.00
500µg
$900.00
1mg
$1,500.00