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Recombinant Human PDGF-AB



Catalog Number : 100-00AB

Description

PDGFs are disulfide-linked dimers consisting of two 12.0-13.5 kDa polypeptide chains, designated PDGF-A and PDGF-B chains. The three naturally occurring PDGFs; PDGF-AA, PDGF-BB and PDGF-AB, are potent mitogens for a variety of cell types including smooth muscle cells, connective tissue cells, bone and cartilage cells, and some blood cells. The PDGFs are stored in platelet α-granules and are released upon platelet activation. The PDGFs are involved in a number of biological processes, including hyperplasia, chemotaxis, embryonic neuron development, and respiratory tubule epithelial cell development. Two distinct signaling receptors used by PDGFs have been identified and named PDGFR-α and PDGFR-β. PDGFR-α is high-affinity receptor for each of the three PDGF forms. On the other hand, PDGFR-β interacts with only PDGF-BB and PDGF-AB. Recombinant human PDGF-AB is a 25.5 kDa disulfide-linked dimer, consisting of one A chain and one B chains (234 total amino acids).

Additional Information

Source:
E. Coli
 
Purity:
Above 98% as determined by SDS-PAGE Analysis.
 
Cross Reactivity:
Monkey, Mouse
 
Biological Activity
The ED50 as determined by the dose-dependent stimulation of thymidine uptake by BALB/c 3T3 cells is ≤ 1 ng/ml, corresponding to a specific activity of ≥ 1 x 106 units/mg.
 
AA Sequence

alp hachainMSIEEAV PAVCKTRTV IYEIPRSQV DPTSANFLI WPPCVEVKR CTGCCNTSS VKCQPSRVH HRSVKVAKV EYVRKKPKL KEVQVRLEE HLECACATT SLNPDYREE DTGRPRESG KKRKRKRLK PT

betach ainMS LGSLTIAEP AMIAECKTR TEVFEISRR LIDRTNANF LVWPPCVEV QRCSGCCNN RNVQCRPTQ VQLRPVQVR KIGIVRKKP IFKKATVTL GDHLACKCE TVAAARPVT

Research Interest: Stem Cell Research, Immunology, Cancer, Angiogenesis, Neurosciences, Bone Biology
Cell Type: Stem Cells, Neurons
Protein Cross Reactivity: Monkey, Mouse

Availability: In stock

Size Price Qty
2µg
$80.00
10µg
$195.00
100µg
$780.00
500µg
$2,340.00
1mg
$3,900.00