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Recombinant Human p16-INK4a



Catalog Number : 110-02

Description

p16-INK4a is a nuclear protein that regulates the cell cycle by inhibiting cyclin dependent kinase-4 (CDK4) and CDK6. p16-INK4a inhibits CDK activity by binding to the CDK molecules in a manner that interferes with their ability to interact with cyclin D. This activity has the effect of suppressing tumor formation and growth, and of inducing replicative senescence in various normal cells, including stem cells. The expression of p16-INK4a steadily increases with age and tends to accumulate in stem cell compartments. The deletion, rearrangement, or mutation of the p16-INK4a gene is frequently found in melanomas as well as in certain other types of cancer. Recombinant p16-INK4a is a 16.5 kDa protein containing 156 amino acid residues.

Additional Information

Source:
E. Coli
 
Purity:
Above 95% as determined by SDS-PAGE Analysis.
 
Cross Reactivity:
NULL
 
Biological Activity
Data Not Available.
 
AA Sequence
MEPAAGSSM EPSADWLAT AAARGRVEE VRALLEAGA LPNAPNSYG RRPIQVMMM GSARVAELL LLHGAEPNC ADPATLTRP VHDAAREGF LDTLVVLHR AGARLDVRD AWGRLPVDL AEELGHRDV ARYLRAAAG GTRGSNHAR IDAAEGPSD IPD
Research Interest: Stem Cell Research, Cancer
Cell Type: Stem Cells
Protein Cross Reactivity: NULL

Availability: In stock

Size Price Qty
5µg
$80.00
20µg
$195.00
100µg
$780.00
500µg
$2,340.00
1mg
$3,900.00