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Recombinant Human NOV



Catalog Number : 120-26

Description

NOV is a member of the CCN family of secreted cysteine rich regulatory proteins. The full length NOV protein contains four structural domains that confer distinct, and sometimes opposing, biological activities. Elevated expression of NOV is associated with certain tumors, including Wilm’s tumor and most nephroblastomas. However, in other tumor types and certain cancer cell lines, increased tumorgenicity and proliferation is correlated with decreased NOV expression. Additionally, NOV induces cell adhesion and cell migration by signaling through specific cell surface integrins and by binding to heparin sulfate proteoglycans and to fibulin 1C. NOV has also been reported to exert proangiogenic activities. Recombinant human NOV is a 36.2 kDa protein containing 331 amino acid residues. It is composed of four distinct structural domains (modules); the IGF binding protein (IGFBP) domain, the von Willebrand Factor C (VWFC) domain, the Thrombospondin type-I (TSP type-1) domain, and a C-terminal cysteine knot-like domain (CTCK).

Additional Information

Source:
E. Coli
 
Purity:
Above 95% as determined by SDS-PAGE Analysis.
 
Cross Reactivity:
Mouse
 
Biological Activity
Determined by a cell proliferation assay using BALB/c 3T3 cells. The expected ED50 for this effect is 1.0-2.0 μg/ml
 
AA Sequence
MQVAATQRC PPQCPGRCP ATPPTCAPG VRAVLDGCS CCLVCARQR GESCSDLEP CDESSGLYC DRSADPSNQ TGICTAVEG DNCVFDGVI YRSGEKFQP SCKFQCTCR DGQIGCVPR CQLDVLLPE PNCPAPRKV EVPGECCEK WICGPDEED SLGGLTLAA YRPEATLGV EVSDSSVNC IEQTTEWTA CSKSCGMGF STRVTNRNR QCEMLKQTR LCMVRPCEQ EPEQPTDKK GKKCLRTKK SLKAIHLQF KNCTSLHTY KPRFCGVCS DGRCCTPHN TKTIQAEFQ CSPGQIVKK PVMVIGTCT CHTNCPKNN EAFLQELEL KTTRGKM
Research Interest: Cancer, Angiogenesis, Proliferation and Cell Cycle
Protein Cross Reactivity: Mouse

Availability: In stock

Size Price Qty
5µg
$80.00
20µg
$195.00
100µg
$780.00
500µg
$2,340.00
1mg
$3,900.00