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Recombinant Human NNT-1/BCSF-3



Catalog Number : 450-18

Description

NNT-1/BCSF-3 is a neurotrophic factor with B-cell stimulating capabilities. Expressed in lymph nodes and spleen, NNT-1/BCSF-3 binds and activates glycoprotein 130 (gp130) and leukemia inhibitory factor receptor member β (LIFR-β) and induces tyrosine phosphorylation of these receptors. In vitro, it supports the survival of chick embryo motor and sympathetic neurons. In mice, NNT-1/BCSF-3 induces serum amyloid A, causes body weight loss and B cell hyperplasia associated with increased in serum IgG and IgM. Recombinant human NNT-1/BCSF-3 is a 22.4 kDa protein containing 199 amino acid residues.

Additional Information

Source:
E. Coli
 
Purity:
Above 98% as determined by SDS-PAGE Analysis.
 
Cross Reactivity:
Chicken
 
Biological Activity
NT-1/BCSF-3 weakly supports chick E8 DRG neurite outgrowth at a concentration of 1.0 ng/ml.
 
AA Sequence
MLNRTGDPG PGPSIQKTY DLTRYLEHQ LRSLAGTYL NYLGPPFNE PDFNPPRLG AETLPRATV DLEVWRSLN DKLRLTQNY EAYSHLLCY LRGLNRQAA TAELRRSLA HFCTSLQGL LGSIAGVMA ALGYPLPQP LPGTEPTWT PGPAHSDFL QKMDDFWLL KELQTWLWR SAKDFNRLK KKMQPPAAA VTLHLGAHG F
Research Interest: Immunology, Neurosciences, Metabolic Regulation and Diabetes
Cell Type: B Cells, Neurons
Protein Cross Reactivity: Chicken

Availability: In stock

Size Price Qty
2µg
$80.00
10µg
$195.00
100µg
$1,040.00
500µg
$3,120.00
1mg
$5,200.00