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Recombinant Human Neuroserpin



Catalog Number : 130-14

Description

Neuroserpin is an inhibitory serpin that is expressed predominantly in central nervous system. Although the physiological target of neuroserpin is still unclear, cumulative evidence suggest that it plays an important role in controlling proteolytic degradation of extracellular matrix (ECM) during synaptogenesis and the subsequent development of neuronal plasticity. In the adult brain, neuroserpin is secreted from the growth cones of neurons in areas where synaptic changes are associated with learning and memory, i.e. cerebral cortex, hippocampus, and amygdala. The neuroprotective role of neuroserpin has been demonstrated in transgenic mice lacking neuroserpin expression. The deficiency of neuroserpin in these mice was associated with motor neuron disease characterized by axonal degradation. In humans, defects in neuroserpin, caused by point mutations in the neuroserpin gene, underlie a hereditary disorder called the familial encephalopathy with neuroserpin inclusion bodies (FENIB). Recombinant human neuroserpin is a 44.8 kDa non-glycosylated protein containing 395 amino-acid residues.

Additional Information

Source:
E. Coli
 
Purity:
Above 96% as determined by SDS-PAGE Analysis.
 
Cross Reactivity:
Rat
 
Biological Activity
Determined by the dose-dependent stimulation of the proliferation of rat C6 cells using a concentration range of 0.3-0.6 μg/ml.
 
AA Sequence
MTGATFPEE AIADLSVNM YNRLRATGE DENILFSPL SIALAMGMM ELGAQGSTQ KEIRHSMGY DSLKNGEEF SFLKEFSNM VTAKESQYV MKIANSLFV QNGFHVNEE FLQMMKKYF NAAVNHVDF SQNVAVANY INKWVENNT NNLVKDLVS PRDFDAATY LALINAVYF KGNWKSQFR PENTRTFSF TKDDESEVQ IPMMYQQGE FYYGEFSDG SNEAGGIYQ VLEIPYEGD EISMMLVLS RQEVPLATL EPLVKAQLV EEWANSVKK QKVEVYLPR FTVEQEIDL KDVLKALGI TEIFIKDAN LTGLSDNKE IFLSKAIHK SFLEVNEEG SEAAAVSGM IAISRMAVL YPQVIVDHP FFFLIRNRR TGTILFMGR VMHPETMNT SGHDFEEL
Research Interest: Neurosciences
Cell Type: Neurons
Protein Cross Reactivity: Rat

Availability: In stock

Size Price Qty
5µg
$80.00
25µg
$195.00
100µg
$600.00
500µg
$1,800.00
1mg
$3,000.00