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Recombinant Human/Murine/Rat Activin A (E.coli-derived)



Catalog Number : 120-14E

Description

Activin A is a TGF-β family member that exhibits a wide range of biological activities including regulation of cellular proliferation and differentiation, and promotion of neuronal survival. Elevated levels of Activin A in human colorectal tumors and in postmenopausal women have been implicated in colorectal and breast cancers, respectively. The biological activities of Activin A can be neutralized by inhibins and by the diffusible TGF-β antagonist, follistatin. Human/Murine/Rat Activin A is a 26.0 kDa disulfide-linked homodimer of two βA chains, each containing 116 amino acid residues.

Additional Information

Source:
E. Coli
 
Purity:
Above 97% as determined by SDS-PAGE Analysis.
 
Cross Reactivity:
Chicken, Dog, Frog, Mouse, Human + Mouse
 
Biological Activity
The ED50 as determined by its ability to inhibit the proliferation of murine MPC-11 cells is ≤ 2.0 ng/ml, corresponding to a specific activity of ≥ 5 x 105 units/mg.
 
AA Sequence
GLECDGKVN ICCKKQFFV SFKDIGWND WIIAPSGYH ANYCEGECP SHIAGTSGS SLSFHSTVI NHYRMRGHS PFANLKSCC VPTKLRPMS MLYYDDGQN IIKKDIQNM IVEECGCS
Research Interest: Stem Cell Research, Apoptosis, Cancer, Angiogenesis, Neurosciences, Proliferation and Cell Cycle
Cell Type: T Cells
Protein Cross Reactivity: Chicken, Dog, Frog, Mouse, Human + Mouse

Availability: In stock

Size Price Qty
2µg
$80.00
10µg
$195.00
100µg
$1,040.00
500µg
$3,120.00
1mg
$5,200.00