Creating Value for Life Science Research!


Get a Free Sample of this product!
shopping cart image

Recombinant Human MIF



Catalog Number : 300-69

Description

Macrophage Migration Inhibitory Factor (MIF) is a small secreted protein that can act as a pleiotropic pro-inflammatory cytokine as well as an enzyme. MIF pro-inflammatory activity can be initiated by signaling through CD74 and CD44, resulting in the secretion of TNF-α, IL-1, IL-6, IL-8, and various MMPs. The enzymatic activity of MIF is characterized by its ability to act as a tautomerase, capable of catalyzing the keto to enol isomerization of keto-phenylpyruvate and L-dopachrome. It appears as though MIF catalytic activity is dependent upon a trimeric configuration and a free N-terminal proline residue. Insect cell derived recombinant MIF is a 15 kDa protein containing 124 amino acid residues, including an N-terminal His-tag.

Additional Information

Source:
Hi-5 Insect cells
 
Purity:
Above 98% as determined by SDS-PAGE Analysis.
 
Cross Reactivity:
NULL
 
Biological Activity
Determined by its ability to inhibit monocyte migration.
 
AA Sequence
HHHHHHHHA MPMFIVNTN VPRASVPDG FLSELTQQL AQATGKPPQ YIAVHVVPD QLMAFGGSS EPCALCSLH SIGKIGGAQ NRSYSKLLC GLLAERLRI SPDRVYINY YDMNAANVG WNNSTFA
Research Interest: Innate Immunity, Inflammation
Cell Type: Monocytes and Macrophages
Protein Cross Reactivity: NULL

Availability: In stock

Size Price Qty
5µg
$80.00
25µg
$195.00
100µg
$600.00
500µg
$1,800.00
1mg
$3,000.00