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Recombinant Human Lin28-TAT



Catalog Number : 110-06

Description

Lin28 is a RNA-binding protein that belongs to a diverse family of structurally-related transcription factors. Lin28 is found abundantly in embryonic stem cells (ESCs), and to a lesser extent in placenta and testis. Lin28 has been shown to block let-7 microRNA processing and maturation, a necessary step in the differentiation of stem cells and certain cancer cell lines. Together with Sox2, Oct4, and Nanog, Lin28 can induce the reprogramming of primary human fibroblasts to a pluripotent state. Lin28 and other regulatory proteins can be introduced into cells by DNA transfection, viral infection, or microinjection. Protein transduction using TAT fusion proteins represents an alternative methodology for introducing proteins into primary as well as transformed cells. Recombinant human Lin28-TAT is a 24.4 kDa protein containing 222 amino acid residues, including 13- residue C-terminal TAT peptide.

Additional Information

Source:
E. Coli
 
Purity:
Above 90% as determined by SDS-PAGE Analysis.
 
Cross Reactivity:
NULL
 
Biological Activity
Measured by its ability to induce fluorescence in Lin28 reporter cells (293 cells transfected with fluorescent protein genes under Lin28 control). Optimum activity was achieved at 20 μg/ml after incubation for 72 hr.
 
AA Sequence
GPSVSNQQF AGGCAKAAE EAPEEAPED AARAADEPQ LLHGAGICK WFNVRMGFG FLSMTARAG VALDPPVDV FVHQSKLHM EGFRSLKEG EAVEFTFKK SAKGLESIR VTGPGGVFC IGSERRPKG KSMQKRRSK GDRCYNCGG LDHHAKECK LPPQPKKCH FCQSISHMV ASCPLKAQQ GP
Research Interest: Stem Cell Research, Cancer
Cell Type: Stem Cells
Protein Cross Reactivity: NULL

Availability: In stock

Size Price Qty
5µg
$80.00
25µg
$195.00
100µg
$600.00
500µg
$1,800.00
1mg
$3,000.00