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Recombinant Human LIGHT



Catalog Number : 310-09B

Description

LIGHT belongs to the TNF family of ligands, and can signal through the herpes virus entry mediator type A receptor (HVEM, TNFRSF14), LTβR, or bind to a decoy receptor, DcR3. It is expressed in splenocytes, activated PBL, CD+8 tumor infiltrating lymphocytes, granulocytes, and monocytes. LIGHT has the ability to active NFκB, to co-stimulate the activation of lymphocytes and to induce apoptosis in certain human tumor cells. Recombinant human LIGHT has a calculated mass of 19.3 kDa containing 177 amino acid residues. Due to glycosylation LIGHT migrates between 20.0-22.5 kDa by SDS-PAGE under non-reducing conditions.

*Human LIGHT(Catalog Number 310-09B) has replaced Human LIGHT(Catalog Number 310-09)

Additional Information

Source:
Hi-5 Insect cells
 
Purity:
Above 95% as determined by SDS-PAGE Analysis.
 
Cross Reactivity:
NULL
 
Biological Activity
Determined by its cytotoxic effect on HT-29 cells (human colon adenocarcinoma cells) in the presence of human IFN-gamma.
 
AA Sequence
RLGEMVTRL PDGPAGSWE QLIQERRSH EVNPAAHLT GANSSLTGS GGPLLWETQ LGLAFLRGL SYHDGALVV TKAGYYYIY SKVQLGGVG CPLGLASTI THGLYKRTP RYPEELELL VSQQSPCGR ATSSSRVWW DSSFLGGVV HLEAGEKVV VRVLDERLV RLRDGTRSY FGAFMV
Research Interest: Apoptosis
Cell Type: Monocytes and Macrophages
Protein Cross Reactivity: NULL

Availability: In stock

Size Price Qty
3µg
$80.00
15µg
$195.00
100µg
$800.00
500µg
$2,400.00
1mg
$4,000.00